When Slim is left to take care of the ranch and little Alfred, who has the measles, he gets sick himself and a freak blizzard sets in, so it is up Hank to try to keep things under control.

When the ranch falls on hard times, Slim the cowboy decides to hit the road in search of a new job and inadvertently takes Hank and Drover with him.

After Hank's ranch is robbed by a saddle thief, a new dog arrives on the ranch, unraveling a series of mysterious events.

Hank the cowdog investigates the mystery of a cattle rustler who works by night.

In the course of his job as Head of Ranch Security, Hank the dog is asked to guard five chicks, despite the fact that poultry is his favorite kind of dinner.

While battling a "blinded" blizzard to get cough syrup for Baby Mollie, fearless Hank charms Miss Beulah the Collie Dog, saves Slim and Drover from freezing, sings a love song about fleas, and outwits Pete the Barncat.

In his own modest way, Hank the Cowdog recounts how he barely escaped crazy Slim and his tail-eating vacuum sweeper and single-handedly saved the ranch from a huge catastrophe.